SMart Nanoparticle–Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing
Hongping Wan, Huirong Tan, Xinghong Zhao · Wiley · 2025
This study presents a smart hydrogel system that enhances wound healing and infection control through targeted photothermal therapy.
Plain English summary
Why this matters
Key findings
- Developed a multifunctional hydrogel integrated with photothermal nanoparticles.
- Nanoparticles selectively target Staphylococcus aureus and generate heat for bacterial eradication.
- Hydrogel exhibits strong tissue adhesion and heat-induced contraction.
- System allows for controlled drug release and prevents tissue overheating.
- Achieves rapid wound healing and effective infection control within one week.
What's new
The integration of targeted photothermal therapy with a smart hydrogel for enhanced wound healing and infection control is a novel approach.
Limitations
The abstract does not provide details on the scalability or long-term effects of the treatment.
Commercial context
The abstract does not mention any commercial availability or readiness of the developed system.
Publication
- Publisher
- Wiley
- Publication date
- November 30, 2025
- Research type
- Paper
- License
- http://creativecommons.org/licenses/by/4.0/
Tags
More on Hydrogels
See all →Smart Hydrogel Systems for Skin Fibrosis: Rational Design, Mechanisms, and Therapeutic Applications
This review discusses the design and therapeutic potential of smart hydrogels for treating skin fibrosis.
Smart hydrogel bioinks integrated with two-dimensional nanomaterials for cardiovascular bioprinting and atherosclerosis modeling
This review highlights the potential of smart hydrogel bioinks integrated with nanomaterials for improving cardiovascular disease modeling and bioprinting.
Multifunctional Hydrogel-Based Scaffolds: Integrating Conductive Nanomaterials for Smart Wound Healing Applications
This review highlights the potential of multifunctional hydrogel scaffolds integrated with conductive materials for advanced wound healing solutions.
Smart hydrogel dressings for advanced wound healing: from biomaterial design to microenvironment modulation
Smart hydrogel dressings are designed to enhance wound healing by modulating the microenvironment and promoting tissue regeneration.
Smart Hydrogel Architectures for Sensors: Narrative Review
This review highlights advances in hydrogel sensors for real-time monitoring in healthcare applications.
From Smart Hydrogel Design to 4D-Printed Scaffolds: Emerging Paradigms in Precision Drug Delivery and Regenerative Wound Therapy
This review explores the design and application of smart hydrogels and 4D-printed scaffolds for drug delivery and wound healing.
Recently published
Latest research →Reactive polar mesogenic self-assembly approach enables domain-programmable polymer ferroelectrics
This research introduces a method for creating flexible ferroelectric polymers with programmable polar architectures for advanced electronic applications.
A modular block-based acoustic metamaterial absorber with coiled cavities for enhanced sound absorption
This research presents a modular acoustic metamaterial with tunable sound absorption capabilities for low-frequency applications.
A Comprehensive Study on the Development of Stimuli-Responsive Smart Polymer Systems for Controlled Drug Delivery
This study highlights the potential of multi-stimulus responsive smart polymers for enhanced drug delivery systems.
Bio-inspired re-entrant honeycomb metamaterial with programmable dual-plateau mechanical response
A bio-inspired re-entrant honeycomb mechanical metamaterial is described as having a programmable dual-plateau mechanical response.
