Recent developments in some types of smart stimuli-responsive polymers in advanced drug delivery systems and medicine, A mini review

Dhuha Sabah Hasan, Omar A. Khorsheed, Mohammed H. I. Alluaibi, Hashim J. Abdullah · University of Mosul · 2026

Recent advancements in smart stimuli-responsive polymers enhance drug delivery systems through multi-responsive capabilities.

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Plain English summary

This mini-review highlights recent developments in smart polymers, particularly those that respond to various stimuli like pH, temperature, and light. These materials can change their properties in response to internal and external triggers, making them suitable for advanced drug delivery systems.

Why this matters

The research on smart polymers is crucial for improving drug delivery methods, allowing for more precise and controlled release of medications. This can lead to better therapeutic outcomes and reduced side effects, which is important for patient care in healthcare settings.

Key findings

  • Smart polymers can undergo reversible transitions triggered by various stimuli.
  • Bio-responsive and light-activated polymers offer specific control for drug delivery.
  • Multi-responsive systems improve adaptability and drug-release profiles.
  • Current challenges include structural complexity and biocompatibility.
  • pH- and thermo-responsive polymers are closer to clinical use than others.

What's new

The focus on multi-responsive systems that combine two or more stimuli for enhanced adaptability and therapeutic precision is a significant advancement.

Limitations

The review notes challenges related to structural complexity, long-term biocompatibility, and the clinical readiness of newer systems.

Commercial context

The technologies discussed are still facing challenges that affect their clinical readiness and scalability.

Publication

Publisher
University of Mosul
Publication date
April 8, 2026
Research type
Article
License
https://creativecommons.org/licenses/by/4.0/

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