Stimuli-Responsive Nanocarriers for Targeted Drug Delivery: Design Strategies, Clinical Progress, and Translational Challenges
Lakshmikanta Lakshmikanta, Vaishalli Vaishalli, Mayank David Raiborde, G Kranthi Kishore, P. S. Vikhe, Mushini Srikanthakumari · Dr. Yashwant Research Labs Pvt. Ltd. · 2026
Stimuli-responsive nanocarriers are advanced systems designed to release drugs in response to specific biological or external signals, enhancing targeted drug delivery.
Plain English summary
Why this matters
Key findings
- Stimuli-responsive nanocarriers can respond to both endogenous and exogenous signals.
- They aim to maximize drug concentration at the target site while minimizing side effects.
- The review highlights various types of stimuli-responsive systems, including pH-sensitive and thermosensitive carriers.
- Clinical translation is hindered by biological variability and complex manufacturing processes.
- Future advancements depend on programmable designs and better patient selection.
What's new
The review critically evaluates the current state of stimuli-responsive nanocarriers, distinguishing between clinically approved and investigational systems, and emphasizes the need for simpler designs.
Limitations
The abstract notes that clinical translation is limited by factors such as biological heterogeneity, complex manufacturing, and regulatory uncertainty.
Commercial context
The clinical translation of stimuli-responsive systems remains limited and requires further development and validation.
Publication
- Publisher
- Dr. Yashwant Research Labs Pvt. Ltd.
- Publication date
- June 17, 2026
- Research type
- Paper
Tags
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